Research achievement

1. Effects of iguratimod on glucocorticoid-induced disorder of bone metabolism in vitro. J Bone Miner Metab. 2021 Feb 9. Miyama A, Ebina K, Hirao M, Okamura G, Etani Y, Takami K, Goshima A, Miura T, Oyama S, Kanamoto T, Yoshikawa H, Nakata K.

2. Drug retention of sarilumab, baricitinib, and tofacitinib in patients with rheumatoid arthritis: the ANSWER cohort study. Clin Rheumatol. 2021 Jan 29. Ebina K, Hirano T, Maeda Y, Yamamoto W, Hashimoto M, Murata K, Onishi A, Jinno S, Hara R, Son Y, Amuro H, Takeuchi T, Yoshikawa A, Katayama M, Yamamoto K, Hirao M, Okita Y, Kumanogoh A, Nakata K

3. Promoting Effect of Basic Fibroblast Growth Factor in Synovial Mesenchymal Stem Cell-Based Cartilage Regeneration. Int J Mol Sci. 2020 Dec 30;22(1):300.Okamura G, Ebina K, Hirao M, Chijimatsu R, Yonetani Y, Etani Y, Miyama A, Takami K, Goshima A, Yoshikawa H, Ishimoto T, Nakano T, Hamada M, Kanamoto T, Nakata K.

4. Effects of prior osteoporosis treatment on early treatment response of romosozumab in patients with postmenopausal osteoporosis. Bone. 2020 Nov;140:115574. Ebina K, Hirao M, Tsuboi H, Nagayama Y, Kashii M, Kaneshiro S, Miyama A, Nakaya H, Kunugiza Y, Okamura G, Etani Y, Takami K, Goshima A, Nakata K.

5. Combined effect of teriparatide and an anti-RANKL monoclonal antibody on bone defect regeneration in mice with glucocorticoid-induced osteoporosis. Bone. 2020 Oct;139:115525.Etani Y, Ebina K, Hirao M, Kitaguchi K, Kashii M, Ishimoto T, Nakano T, Okamura G, Miyama A, Takami K, Goshima A, Kanamoto T, Nakata K, Yoshikawa H.

6. Drug retention of 7 biologics and tofacitinib in biologics-naïve and biologics-switched patients with rheumatoid arthritis: the ANSWER cohort study. Arthritis Res Ther. 2020 Jun 15;22(1):142.Ebina K, Hirano T, Maeda Y, Yamamoto W, Hashimoto M, Murata K, Takeuchi T, Shiba H, Son Y, Amuro H, Onishi A, Akashi K, Hara R, Katayama M, Yamamoto K, Kumanogoh A, Hirao M.

7. Effects of follow-on therapy after denosumab discontinuation in patients with postmenopausal osteoporosis. Mod Rheumatol. 2021 Mar;31(2):485-492.Ebina K, Hashimoto J, Kashii M, Hirao M, Miyama A, Nakaya H, Tsuji S, Takahi K, Tsuboi H, Okamura G, Etani Y, Takami K, Yoshikawa H.

8. Drug retention of secondary biologics or JAK inhibitors after tocilizumab or abatacept failure as first biologics in patients with rheumatoid arthritis -the ANSWER cohort study. Clin Rheumatol. 2020 Sep;39(9):2563-2572.Ebina K, Hirano T, Maeda Y, Yamamoto W, Hashimoto M, Murata K, Takeuchi T, Nagai K, Son Y, Amuro H, Onishi A, Jinno S, Hara R, Katayama M, Yamamoto K, Kumanogoh A, Hirao M.

9. Radiographic effects observed in the coronal view after medial malleolar osteotomy at total ankle arthroplasty in rheumatoid arthritis cases. J Orthop Sci. 2020 Nov;25(6):1072-1078.Hirao M, Hashimoto J, Ebina K, Tsuboi H, Takahi K, Nakaya H, Noguchi T, Kunugiza Y, Tsuji S, Yoshikawa H.

10. A report of three cases which required tibialis anterior tendon resection to recover delayed wound healing after total ankle arthroplasty in patients with rheumatoid arthritis. Mod Rheumatol Case Rep. 2020 Jan;4(1):6-10.Etani Y, Ebina K, Hirao M, Miyama A, Hashimoto J, Noguchi T, Okamura G, Takami K, Yoshikawa H.

11. Drug tolerability and reasons for discontinuation of seven biologics in elderly patients with rheumatoid arthritis -The ANSWER cohort study. PLoS One. 2019 May 8;14(5):e0216624.Ebina K, Hashimoto M, Yamamoto W, Hirano T, Hara R, Katayama M, Onishi A, Nagai K, Son Y, Amuro H, Yamamoto K, Maeda Y, Murata K, Jinno S, Takeuchi T, Hirao M, Kumanogoh A, Yoshikawa H.

12. Correction to: Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis-the ANSWER cohort study. Arthritis Res Ther. 2019 May 6;21(1):114.Ebina K, Hashimoto M, Yamamoto W, Hirano T, Hara R, Katayama M, Onishi A, Nagai K, Son Y, Amuro H, Yamamoto K, Maeda Y, Murata K, Jinno S, Takeuchi T, Hirao M, Kumanogoh A, Yoshikawa H.

13. Effects of range of motion exercise of the metatarsophalangeal joint from 2-weeks after joint-preserving rheumatoid forefoot surgery. Mod Rheumatol. 2020 Mar;30(2):305-312.Hirao M, Tsuboi H, Tazaki N, Kushimoto K, Ebina K, Yoshikawa H, Hashimoto J.

14. Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis-the ANSWER cohort study. Arthritis Res Ther. 2019 Apr 11;21(1):91.Ebina K, Hashimoto M, Yamamoto W, Hirano T, Hara R, Katayama M, Onishi A, Nagai K, Son Y, Amuro H, Yamamoto K, Maeda Y, Murata K, Jinno S, Takeuchi T, Hirao M, Kumanogoh A, Yoshikawa H.

15. Impact of combining medial capsule interposition with modified scarf osteotomy for hallux valgus. Mod Rheumatol. 2020 Jan;30(1):204-210.Ebina K, Hirao M, Tsuboi H, Kaneshiro S, Nishikawa M, Goshima A, Noguchi T, Nakaya H, Etani Y, Miyama A, Takami K, Hashimoto J, Yoshikawa H.

16. Modified Scarf Osteotomy with Medial Capsular Interposition in Great Toe and Metatarsal Shortening Offset Osteotomy in Lesser Toes for Rheumatoid Deformity. JBJS Essent Surg Tech. 2018 Oct 24;8(4):e27.Hirao M, Ebina K, Tsuboi H, Nampei A, Tsuji S, Noguchi T, Owaki H, Yoshikawa H, Hashimoto J.

17. The add-on effectiveness and safety of iguratimod in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab. Mod Rheumatol. 2019 Jul;29(4):581-588.Ebina K, Miyama A, Tsuboi H, Kaneshiro S, Nishikawa M, Owaki H, Tsuji S, Hirao M, Etani Y, Goshima A, Hashimoto J, Yoshikawa H.

18. Use of autologous bone grafting from the calcaneus and interconnected porous hydroxyapatite ceramic for bone transplantation in rheumatoid foot surgery. SAGE Open Med Case Rep. 2018 Jun 25;6:2050313X18784413.Hirao M, Ebina K, Etani Y, Tsuboi H, Noguchi T, Tsuji S, Hashimoto J, Yoshikawa H.

19. Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-κB pathway. Biochem Biophys Res Commun. 2018 Sep 5;503(2):644-650.Noguchi T, Ebina K, Hirao M, Otsuru S, Guess AJ, Kawase R, Ohama T, Yamashita S, Etani Y, Okamura G, Yoshikawa H.

20. Administration of Oxygen Ultra-Fine Bubbles Improves Nerve Dysfunction in a Rat Sciatic Nerve Crush Injury Model. Int J Mol Sci. 2018 May 7;19(5):1395.Matsuoka H, Ebina K, Tanaka H, Hirao M, Iwahashi T, Noguchi T, Suzuki K, Nishimoto S, Murase T, Yoshikawa H.

21. Modified Scarf Osteotomy with Medial Capsule Interposition for Hallux Valgus in Rheumatoid Arthritis: A Study of Cases Including Severe First Metatarsophalangeal Joint Destruction. J Bone Joint Surg Am. 2018 May 2;100(9):765-776.Kushioka J, Hirao M, Tsuboi H, Ebina K, Noguchi T, Nampei A, Tsuji S, Akita S, Hashimoto J, Yoshikawa H.

22. Impact of switching oral bisphosphonates to denosumab or daily teriparatide on the progression of radiographic joint destruction in patients with biologic-naïve rheumatoid arthritis. Osteoporos Int. 2018 Jul;29(7):1627-1636.Ebina K, Hirao M, Hashimoto J, Matsuoka H, Iwahashi T, Chijimatsu R, Etani Y, Okamura G, Miyama A, Yoshikawa H.

23. Drug retention and discontinuation reasons between seven biologics in patients with rheumatoid arthritis -The ANSWER cohort study. PLoS One. 2018 Mar 15;13(3):e0194130.Ebina K, Hashimoto M, Yamamoto W, Ohnishi A, Kabata D, Hirano T, Hara R, Katayama M, Yoshida S, Nagai K, Son Y, Amuro H, Akashi K, Fujimura T, Hirao M, Yamamoto K, Shintani A, Kumanogoh A, Yoshikawa H.

24. Impact of dexamethasone concentration on cartilage tissue formation from human synovial derived stem cells in vitro. Cytotechnology. 2018 Apr;70(2):819-829.Chijimatsu R, Kobayashi M, Ebina K, Iwahashi T, Okuno Y, Hirao M, Fukuhara A, Nakamura N, Yoshikawa H.

25. Total Ankle Arthroplasty for Rheumatoid Arthritis in Japanese Patients: A Retrospective Study of Intermediate to Long-Term Follow-up. JB JS Open Access. 2017 Nov 28;2(4):e0033.Hirao M, Hashimoto J, Tsuboi H, Ebina K, Nampei A, Noguchi T, Tsuji S, Nishimoto N, Yoshikawa H.

26. Comparison of the effects of forefoot joint-preserving arthroplasty and resection-replacement arthroplasty on walking plantar pressure distribution and patient-based outcomes in patients with rheumatoid arthritis. PLoS One. 2017 Aug 29;12(8):e0183805.Ebina K, Hirao M, Takagi K, Ueno S, Morimoto T, Matsuoka H, Kitaguchi K, Iwahashi T, Hashimoto J, Yoshikawa H.

27. Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis. J Bone Miner Metab. 2018 Jul;36(4):478-487.Ebina K, Hirao M, Hashimoto J, Hagihara K, Kashii M, Kitaguchi K, Matsuoka H, Iwahashi T, Chijimatsu R, Yoshikawa H.

28. Outcomes of modified metatarsal shortening offset osteotomy for forefoot deformity in patients with rheumatoid arthritis: Short to mid-term follow-up. Mod Rheumatol. 2017 Nov;27(6):981-989.Hirao M, Ebina K, Tsuboi H, Nampei A, Kushioka J, Noguchi T, Tsuji S, Owaki H, Hashimoto J, Yoshikawa H.

29. Comparison of a self-administered foot evaluation questionnaire (SAFE-Q) between joint-preserving arthroplasty and resection-replacement arthroplasty in forefoot surgery for patients with rheumatoid arthritis. Mod Rheumatol. 2017 Sep;27(5):795-800.Ebina K, Hirao M, Hashimoto J, Nampei A, Shi K, Tomita T, Futai K, Kunugiza Y, Noguchi T, Yoshikawa H.

30. Oxygen ultra-fine bubbles water administration prevents bone loss of glucocorticoid-induced osteoporosis in mice by suppressing osteoclast differentiation. Osteoporos Int. 2017 Mar;28(3):1063-1075.Noguchi T, Ebina K, Hirao M, Morimoto T, Koizumi K, Kitaguchi K, Matsuoka H, Iwahashi T, Yoshikawa H.

31. Comparison of the effects of denosumab between a native vitamin D combination and an active vitamin D combination in patients with postmenopausal osteoporosis. J Bone Miner Metab. 2017 Sep;35(5):571-580.Ebina K, Kashii M, Hirao M, Hashimoto J, Noguchi T, Koizumi K, Kitaguchi K, Matsuoka H, Iwahashi T, Tsukamoto Y, Yoshikawa H.

32. Appearance of hindfoot valgus deformity and recurrence of hallux valgus in the very early period after hallux valgus surgery in a poorly controlled rheumatoid arthritis case: A case report. Mod Rheumatol. 2019 Mar;29(2):367-369.Hirao M, Ebina K, Tsuboi H, Noguchi T, Hashimoto J, Yoshikawa H.

33. Association between preoperative pain intensity of MTP joint callosities of the lesser toes and fore-mid-hindfoot deformities in rheumatoid arthritis cases. Mod Rheumatol. 2017 Jan;27(1):50-53.Hirao M, Ebina K, Shi K, Tomita T, Noguchi T, Tsuboi H, Hashimoto J, Yoshikawa H.

34. The efficacy and safety of additional administration of tacrolimus in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab. Mod Rheumatol. 2017 Jan;27(1):42-49.Kaneshiro S, Ebina K, Hirao M, Tsuboi H, Nishikawa M, Nampei A, Nagayama Y, Takahi K, Noguchi T, Owaki H, Hashimoto J, Yoshikawa H.

35. Hallux valgus deformity after total ankle arthroplasty for rheumatoid arthritis: A case report. Mod Rheumatol. 2018 Sep;28(5):890-892.Hirao M, Hirai Y, Ebina K, Shi K, Noguchi T, Tsuboi H, Hashimoto J, Yoshikawa H.

36. Comparison of the effects of 12 months of monthly minodronate monotherapy and monthly minodronate combination therapy with vitamin K2 or eldecalcitol in patients with primary osteoporosis. J Bone Miner Metab. 2016 May;34(3):243-50.Ebina K, Noguchi T, Hirao M, Kaneshiro S, Tsukamoto Y, Yoshikawa H.

37. Association between preoperative pain intensity of MTP joint callosities of the lesser toes and fore-mid-hindfoot deformities in rheumatoid arthritis cases Mod Rheumatol. 2016. June 16. [Epub ahead of print] Hirao M, Ebina K, Shi K, Tomita T, Noguchi T, Tsuboi H, Hashimoto J, Yoshikawa H.

38. Synovial mesenchymal stem cells from osteo- or rheumatoid arthritis joints exhibit good potential for cartilage repair using a scaffold-free tissue engineering approach Osteoarthritis and Cartilage. 2016. Mar 10. pii: S1063-4584(16)01064-5. Koizumi K, Ebina K, Hart DA, Hirao M, Noguchi T, Sugita N, Yasui Y, Chijimatsu R, Yoshikawa H, Nakamura N.

39. The effects of switching daily teriparatide to oral bisphosphonates or denosumab in patients with primary osteoporosis J Bone Miner Metab. 2016. Jan 13. [Epub ahead of print] Ebina K, Hashimoto J, Masafumi K, Hirao M, Kaneshiro S, Noguchi T, Tsukamoto Y, Yoshikawa H.

40. The efficacy and safety of additional administration of tacrolimus in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab Mod Rheumatol. 2016. May 16:1-8. [Epub ahead of print] Kaneshiro S, Ebina K, Hirao M, Tsuboi H, Nishikawa M, Nampei A, Nagayama Y, Takahi K, Noguchi T, Owaki H, Hashimoto J, Yoshikawa H. 　

41. Hallux valgus deformity after total ankle arthroplasty for rheumatoid arthritis: a case report Mod Rheumatol. 2016. May 4:1-3. [Epub ahead of print] Hirao M, Hirai Y, Ebina K, Shi K, Noguchi T, Tsuboi H, Hashimoto J, Yoshikawa H. 　

42. Effects of switching weekly alendronate or risedronate to monthly minodronate in patients with rheumatoid arthritis: a twelve-month prospective study Osteoporosis International, 2015. Oct 16. [Epub ahead of print] Ebina K, Noguchi T, Hashimoto J, Hirao M, Kaneshiro S, Yukioka M, Yoshikawa H. 　

43. Undercarboxylated osteocalcin may be an attractive marker of teriparatide treatment in RA patients: response to Mokuda Osteoporosis International, 2015. Apr;26(4):1445. Ebina K, Hashimoto J, Shi K, Kashii M, Hirao M, Yoshikawa H. 　

44. Comparison of the effects of 12 months monthly minodronate monotherapy and monthly minodronate combination therapy with vitamin K2 or eldecalcitol in patients with primary osteoporosis J Bone Miner Metab. 2015. Aug 25. [Epub ahead of print] Ebina K, Noguchi T, Hirao M, Tsukamoto Y, Kaneshiro S, Yoshikawa H.

45. Semaphorin 4D contributes to rheumatoid arthritis by inducing inflammatory cytokine production: Pathogenic and therapeutic implications. Arthritis Rheumatol. 2015. Jun;67(6):1481-90. Yoshida Y, Ogata A, Kang S, Ebina K, Shi K, Nojima S, Kimura T, Ito D, Morimoto K, Nishide M, Hosokawa T, Hirano T, Shima Y, Narazaki M, Tsuboi H, Saeki Y, Tomita T, Tanaka T, Kumanogoh A.

46. Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice. Biochem Biophys Res Commun. 2015. Sep 25;465(3):638-43. Noguchi T, Ebina K, Hirao M, Kawase R. et al

47. A case of adolescent giant parathyroid adenoma presenting multiple osteolytic fractures and postoperative hungry bone syndrome. Clinical Case Reports 2015. Oct;3(10):835-40. Ebina K, Miyoshi Y, Izumi S, et al.

48. Multiple subcutaneous xanthogranuloma at juxta-articular sites with bone cystic changes resembling rheumatoid arthritis: A case report Mod Rheumatol. 2015. Dec 23:1-4. [Epub ahead of print] Shoichi Kaneshiro, Kenrin Shi, Kosuke Ebina, Masao Yukioka, Hideki Yoshikawa, and Norikazu Murata.

49. Comparison of the effect of 18-month daily teriparatide administration on patients with rheumatoid arthritis and postmenopausal osteoporosis patients Osteoporosis International, 2014. Dec;25(12):2755-65. doi: 10.1007/s00198-014-2819-x. Epub 2014 Aug 1.PMID:25082556. Ebina K, Hashimoto J, Shi K, Kashii M, Hirao M, Yoshikawa H. 　

50. Circulating sclerostin and dickkopf-1 levels in ossification of the posterior longitudinal ligament of the spine J Bone Miner Metab. 2015 Jun 4. [Epub ahead of print] Kashii M, Matsuo Y, Sugiura T, Fujimori T, Honda H, Kaito T, Ebina K, Iwasaki M.

51. Bruton tyrosine kinase (Btk) suppresses osteoblastic differentiation J Bone Miner Metab. 2015. Sep;33(5):486-95. Shoichi Kaneshiro, Kosuke Ebina, Kenrin Shi, Kiyoshi Yoshida, Dai Otsuki, Hideki Yoshikawa and Chikahisa Higuchi

52. Effect of correction of hindfoot valgus deformity on ankle joint pain relief in rheumatoid arthritis cases: A report of two cases. SAGE Open Medical Case Reports 2014, doi: 10.1177/2050313X14553694 Hirao M, Tsuboi H, Akita S, Matsushita M, Shiro O, Saeki Y, Hashimoto J.

53. Computer assisted planning and custom-made surgical guide for malunited pronation deformity after first metatarsophalangeal joint arthrodesis in rheumatoid arthritis: a case report. Hirao M, Ikemoto S, Tsuboi H, Akita S, Ohshima S, Saeki Y, Yoshikawa H, Sugamoto K, Murase T, Hashimoto J. Comput Aided Surg. 2014;19(1-3):13-9. doi: 10.3109/10929088.2014.885992. Epub 2014 Apr 10.

54. Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. Proc Natl Acad Sci U S A. 2014. Mar 11;111(10):3787-92. Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H.

55. IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro. J Bone Miner Metab. 2014 Jul;32(4):378-92 Kaneshiro S, Ebina K, Shi K, Hirao M, Hashimoto J, Morimoto T, Koizumi K, Yoshikawa H. 　

56. Involvement of valgus hindfoot deformity in hallux valgus deformity in rheumatoid arthritis. Yamada S, Hirao M, Tsuboi H, Akita S, Matsushita M, Ohshima S, Saeki Y, Hashimoto J. Mod Rheumatol. 2014 Sep;24(5):851-4. doi: 10.3109/14397595.2013.874738. Epub 2014 Feb 18.

57. Use of a custom-made surgical guide in total ankle arthroplasty in rheumatoid arthritis cases. Techniques in Orhopaedics. 2014;29: 102-111 Hirao M, Oka K, Ikemoto S, Nakao R, Tsuboi H, Nampei A, Akita S, Shi K, Ebina K et al.

58. Hind-mid-forefoot deformity in hallux valgus deformity in rheumatoid arthritis: Radiographic evaluation grouped by existence of dorsal dislocation of second metarsophalangeal joint. Rheumatol Curr Res. 2013. doi:10.4172/2161-1149. Hirao M, Tsuboi H, Akita S, Koga T, Matsushita M, Ohshima S, et al.

59. Oxygen and air nanobubble water solution promote the growth of plants, fishes, and mice. PLoS One. 2013 Jun 5;8(6):e65339. doi: 10.1371/journal.pone.0065339 Ebina K, Shi K, Hirao M, Hashimoto J, Kawato Y, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H.

60. Prevalence of gastroesophageal reflux disease symptoms and related factors in patients with rheumatoid arthritis. J Clin Biochem Nutr. 2013 Mar;52(2):179-84. doi: 10.3164/jcbn.12-83. Epub 2013 Feb 6. Nampei A, Shi K, Ebina K, Tomita T, Sugamoto K, Yoshikawa H, Hirao M, Hashimoto J. 　　

61. Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis. Mod Rheumatol. 2013 Sep;23(5):1001-7. doi: 10.1007/s10165-012-0789-4. Epub 2012 Nov 6. Kosuke Ebina , Kenrin Shi, Makoto Hirao, Shoichi Kaneshiro, Tokimitsu Morimoto, Kota Koizumi, Hideki Yoshikawa, Jun Hashimoto. 　　

62. Retention of Tocilizumab and Anti-Tumor Necrosis Factor Drugs in the Treatment of Rheumatoid Arthritis Scand J Rheumatol. 2013;42(4):253-9. doi: 10.3109/03009742.2012.762037. Epub 2013 Mar 7. Hishitani Y, Ogata A, Shima Y, Hirano T, Ebina K, Kunugiza Y, Shi K, Narazaki M, Hagihara K, Tomita T, Yoshikawa H, Tanaka T, Kumanogoh A.

63. Hypoxia favors maintenance of the vascular smooth muscle cell phenotype in culture. J Biochem Mol Toxicol. 2012 Oct;26(10):381-3. doi: 10.1002/jbt.21428. Epub 2012 Jul 9. Yamasaki N, Hirao M, Kawato Y, Ebina K, Oze H, Nampei A, Shi K, Yoshikawa H, Hashimoto J. 　

64. Nkx3.2 promotes primary chondrogenic differentiation by upregulating col2a1 transcription. PLoS One. 2012;7(4):e34703. doi: 10.1371/journal.pone.0034703. Epub 2012 Apr 12. Kawato Y, Hirao M, Ebina K, Shi K, Hashimoto J, Honjo Y, Yoshikawa H, Myoui A.

65. Impact of medium volume and oxygen concentration in the incubator on pericellular oxygen concentration and differentiation of murine chondrogenic cell culture. In Vitro Cell Dev Biol Anim. 2012 Feb;48(2):123-30. doi: 10.1007/s11626-011-9479-3. Epub 2012 Jan 19. Oze H, Hirao M, Ebina K, Shi K, Kawato Y, Kaneshiro S, Yoshikawa H, Hashimoto J.

66. Nkx3.2-induced suppression of Runx2 is a crucial mediator of hypoxia-dependent maintenance of chondrocyte phenotypes Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):205-10. doi: 10.1016/j.bbrc.2011.11.026. Epub 2011 Nov 10. Kawato Y, Hirao M, Ebina K, Tamai N, Shi K, Hashimoto J, Yoshikawa H, Myoui A.

67. Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab. Rheumatol Int. 2012 Dec;32(12):4041-5. Hirao Makoto, Yamasaki Naomi, Oze Hiroki, Kosuke Ebina, et al.

68. Diagnostic features of mild cellulitis phlegmon in patients with rheumatoid arthritis treated with tocilizumab: a report of two cases. Mod Rheumatol. 2011 Dec;21(6):673-7. doi: 10.1007/s10165-011-0459-y. Epub 2011 May 1. Hirao M, Nampei A, Shi K, Yoshikawa H, Nishimoto N, Hashimoto J.

69. Laboratory and febrile features after joint surgery in patients with rheumatoid arthritis treated with tocilizumab. Ann Rheum Dis. 2009 May;68(5):654-7. doi: 10.1136/ard.2008.090068. Hirao M, Hashimoto J, Tsuboi H, Nampei A, Nakahara H, Yoshio N, Mima T, Yoshikawa H, Nishimoto N.

70. Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction Clinical　Rheumatology. 2009 Apr;28(4):445-51. Kosuke Ebina, Atsunori Fukuhara, Wataru Ando,et al.

71. Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice Biochem Biophys Res Commun. 2009 Jan 9;378(2):186-91. Kosuke Ebina, Kazuya Oshima, Morihiro Matsuda, et al. 　

72. High oxygen tension prolongs the survival of osteoclast precursors via macrophage colony-stimulating factor. Bone. 2009 Jan;44(1):71-9. doi: 10.1016/j.bone.2008.09.015. Epub 2008 Oct 11. Yamasaki N, Tsuboi H, Hirao M, Nampei A, Yoshikawa H, Hashimoto J.

73. Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women. J Bone Miner Metab. 2008;26(3):260-4. doi: 10.1007/s00774-007-0823-3. Epub 2008 May 11. Hirao M, Hashimoto J, Ando W, Ono T, Yoshikawa H.

74. Oxygen tension is an important mediator of the transformation of osteoblasts to osteocytes. Hirao M, Hashimoto J, Yamasaki N, Ando W, Tsuboi H, Myoui A, Yoshikawa H. J Bone Miner Metab. 2007;25(5):266-76. Epub 2007 Aug 25.

75. Quick-forming hydroxyapatite/agarose gel composites induce bone regeneration. Watanabe J, Kashii M, Hirao M, Oka K, Sugamoto K, Yoshikawa H, Akashi M.　J Biomed Mater Res A. 2007 Dec 1;83(3):845-52.

76. Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification. Hirao M, Tamai N, Tsumaki N, Yoshikawa H, Myoui A. J Biol Chem. 2006 Oct 13;281(41):31079-92. Epub 2006 Aug 11.

77. Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification. Kishida Y, Hirao M, Tamai N, Nampei A, Fujimoto T, Nakase T, Shimizu N, Yoshikawa H, Myoui A. Bone. 2005 Nov;37(5):607-21. Epub 2005 Jul 20.

78. Heterotopic ossification in bilateral knee and hip joints after long-term sedation. Sugita A, Hashimoto J, Maeda A, Kobayashi J, Hirao M, Masuhara K, Yoneda M, Yoshikawa H. J Bone Miner Metab. 2005;23(4):329-32.

79. A new biotechnology for articular cartilage repair: subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2 (rhBMP-2). Tamai N, Myoui A, Hirao M, Kaito T, Ochi T, Tanaka J, Takaoka K, Yoshikawa H. Osteoarthritis Cartilage. 2005 May;13(5):405-17.

80. Macro-structural effect of metal surfaces treated using computer-assisted yttrium-aluminum-garnet laser scanning on bone-implant fixation. Hirao M, Sugamoto K, Tamai N, Oka K, Yoshikawa H, Mori Y, Sasaki T. J Biomed Mater Res A. 2005 May 1;73(2):213-22.