Research achievement

Outani H, Kobayashi E, wasa J, Saito M, Takenaka S, Hayakawa K, Endo M, Takeuchi A, Kobayashi H, Kito M, Morii T, Imanishi J, Ueda T. Clinical outcomes of patients with metastatic solitary fibrous tumors: A Japanese Musculoskeltal Oncology Group (JMOG) multiinstitutional study. Ann Surg Oncol. 2020 Nov 4.

Outani H, Ueda T. ASO Auther reflections: What are the survivorship and prognostic factors of patients with metastatic solitary fibrous tumors? Ann Surg Oncol. 2020 Nov 9.

Takenaka S, Araki N, Outani H, Hamada K, Yoshikawa H, Kamada T, Imai R. Complication rate, functional outcomes, and risk factors associated with carbon ion radiotherapy for patients with unresectable pelvic bone sarcoma. Cancer. 2020 Sep 15;126(18):4188-96.

Imura Y, Tateiwa D, Sugimoto N, Inoue A, Wakamatsu T, Outani H, Tanaka T, Tamiya H, Yagi T, Naka N, Okawa S, Tabuchi T, Takenaka S. Prognostic factors and skeletal-related events in patients with bone metastasis from gastric cancer. Mol Clin Oncol. 2020 Oct;13(4):31.

Takenaka S, Araki N, Outani H, Hamada K, Yoshikawa H, Kamada T, Imai R. Complication rate, functional outcomes, and risk factors associated with carbon ion radiotherapy for patients with unresectable pelvic bone sarcoma. Cancer. 2020 Jul 13.

Outani H, Takenaka S, Hamada K, Imura Y, Kakunaga S, Tamiya H, Wakamatsu T, Naka N, Ueda T, Araki N. A long-term follow-up study of extracorporeal irradiated autografts in limb salvage surgery for malignant bone and soft tissue tumors: A minimum follow-up of 10 years after surgery. J Surg Oncol. 2020 Jun;121(8):1276-1282.

Takenaka S, Araki N, Ueda T, Kakugana S, Imura Y, Hamada K, Outani H, Naka N, Myoui A, Yoshikawa H. Clinical outcomes of osteoarticular extracorporeal irradiated autograft for malignant bone tumor. Sarcoma. 2020 Mar 30;2020:9672093.

Yasuda N, Takenaka S, Nakai S, Nakai T, Yamada S, Imura Y, Outani H, Hamada K, Yoshikawa H, Naka N. TAS-115 inhibits PDGFRa/AXL/FLT-3 signaling and suppresses lung metastasis of osteosarcoma. FEBS Open Bio. 2020 May;10(5):767-779

Outani H, Kakunaga S, Hamada K, Takenaka S, Nakai S, Yasuda N, Imura Y, Naka N, Araki N, Ueda T, Yoshikawa H. Clinical outcomes of chondroblastoma treated using synthetic bone substitute: risk factors for developing radiographic joint degeneration. World J Surg Oncol. 2020 Mar 2;18(1):47.

Nakai S, Tamiya H, Imura Y, Nakai T, Yasuda N, Wakamatsu T, Tanaka T, Outani H, Takenaka S, Hamada K, Myoui A, Araki N, Ueda T, Yoshikawa H, Naka N. Eribulin suppresses clear cell sarcoma growth by inhibiting cell proliferation and inducing melanocytic differentiation both directly and via vascular remodeling. Mol Cancer Ther. 2020 Mar;19(3):742-754.

Hagizawa H, Nagata S, Wakamatsu T, Imura Y, Tanaka T, Outani H, Konishi E, Naka N, Tamiya H. Malignant peripheral nerve sheath tumors in an adolescent patient with mosaic localized NF1: A case report. Mol Clin Oncol. 2020 Feb;12(2):155-159.

Tamiya H, Sabe H, Yamashita K, Imura Y, Wakamatsu T, Takenaka S. Eribulin provides a remarkable effect in Trabectedin-resistant myxoid liposarcoma. Case Rep Orthop. 2020 Nov 12;2020:8873185.

Imura Y, Nagata S, Wakamatsu T, Tanaka T, Tamiya H, Naka N, Takenaka S. A case of Stewart-Treves syndrome occurring in the abdominal wall successfully treated with reibulin: A case report. Mol Clin Oncol. 2020 Nov;13(5):49.

Imuira Y, Yamamoto S, Wakamatsu T, Tanaka T, Tamiya H, Sugimura K, Miyata H, Ishihara R, Yano M, Naka N. Clinical features and prognostic factors in patients with esophageal cancer with bone metastasis. Oncol Lett. 2020 Jan;19(1):717-24.

Imura Y, Takenaka S, Kakunaga S, Nakai T, Wakamatsu T, Outani H, Tanaka T, Tamiya H, Oshima K, Hamada K, Naka N, Araki N, Ueda T, Yoshikawa H. Survival analysis of elderly patients with osteosarcoma. Int Orhtop. 2019 Jul;43(7):1741-1747.

Outani H, Kakunaga S, Hamada K, Takenaka S, Imura Y, Nagata S, Tanaka T, Tamiya H, Oshima K, Naka N, Kudawara I, Araki N, Ueda T, Yoshikawa H. Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and /or adjuvant chemotherapy. Mol Clin Oncol. 2019 Aug;11(2):151-156.

Wakamatus T, Kakunaga S, Takenaka S, Outani H, Hamada K, Imura Y Hori Y, Naka N, Kudawara I, Yoshikawa H, Ueda T. Prongostic implication of adjuvant/neoadjuvant chemotherapy consisting of doxorubicin and ifosfamide in patients with extraskeletal osteosarcoma. Int J Clin Oncol. 2019 Oct;24(10):1311-1319.

Takenaka S, Hamada K, Tanaka H, Outani H, Naka N, Yoshikawa H. Silent subperiosteal iliac hematoma with bone radiolucency in adolescent male athletes. J Orhop. 2019 Aug 13;17:198-202

Tsuda Y, Evans S, Stevenson JD, Parry M, Fujiwara T, Laitinen M, Outani H, Jeys L. Is the width of a surgical margin associated with the outcome of disease in patients with peripheral chondrosarcoma of the pelvis? A Multicenter study. Clin Orthop Relat Res. 2019 Nov;4477(11):2432-2440.

Nakai S, Yamada S, Outani H, Nakai T, Yasuda N, Mae H, Imura Y, Wakamatsu T, Tamiya H, Tanaka T, Hamada K, Tani A, Myoui A, Araki N, Ueda T, Yoshikawa H, Takenaka S, Naka N. Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs. Sci Rep.2019 Nov 1;9(1):15812

Ukon Y, Outani H, Nagata S, Konishi E, Imai R, Demizu Y, Okimoto T, Naka N, Araki N. Rectotumoral fistula formation occurring more than 5 years after carbon ion radiotherapy for sacral chordoma: A case report. Mol Clin Oncol. 2019 May;10(5):4887-491

Yamamoto Y, Kanzaki R, Kanou T, Ose N, Funaki S, Shintani Y, Minami M, Outani H, Takenaka S, Hamada K, Yoshikawa H, Okumura M. Long-term outcomes and prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma. Int J Clin Oncol. 2019 Feb 26

Outani H, Nakamura T, Murata H, Stevenson J, Parry M, Gregory J, Tillman R, Jeys L, Abudu A. Localized synovial sarcoma: A single institutional study of 191 patients with a minimum follow-up of 5 years for survivors. J Surg Oncol. 2019 Feb 20

Tateiwa D, Oshima K, Nakai T, Imura Y, Tanaka T, Outani H, Tamiya H, Araki N, Naka N. Clinical outcomes and significant factors in the survival rate after decompression surgery for patients who were non-ambulatory due to spinal metastases. J Orthop Sci. 2019 Mar;24(2):347-352

Yasuda N, Nakai S, Nakai T, Outani H, Takenaka S, Hamada K, Matsunobu T, Yoshikawa H, Naka N. A pseudoaneurysm of the popliteal artery probably pierced by a bone spike arising in the spontaneously regressed osteochondroma: A case report. J Orthoop Sci. 2018 Oct 11

Outani H, Akita H, Nakai T, Takada T, Imura Y, Tanaka T, Tamiya H, Oshima K, Takahashi H, Ohkawa K, Katayama K, Araki N, Naka N. Clinical features and prognosis of patients with the bone metastasis of pancreatic cancer: a single-institutional cohort study. Pancreas. 2018;47(7):e43-46

Outani H, Imura Y, Tanaka T, Takenaka S, Oshima K, Hamada K, Kakunaga S, Joyama S, Naka N, Kudawara I, Ueda T, Araki N, Yoshikawa H. Clinical outcomes of patients with epithelioid sarcomas: impact and management of nodal metastasis. Int J Clin Oncol. 2018 Feb;23(1):181-188

Ukon Y, Tanaka T, Nagata S, Hagizawa H, Imura Y, Tamiya H, Oshima K, Naka N, Aoki Y, Kuratsu S. Calcific myonecrosis mimicking soft tissue sarcoma: a case report. Oncol Lett. 2018;15(5):909-13

Tateiwa D, Outani H, Iwasa S, Imura Y, Tanaka T, Oshima K, Naka N, Araki N. Atypical femoral fracture associated with bone-modifying agent for bone metastasis of breast cancer: a report of two cases. J Orthop Surg (Hong Kong). 2017;25(3):2309499017727916

Nakai T, Imura Y, Tamiya H, Yamada S, Nakai S, Yasuda N, Kaneko K, Outani H, Takenaka S, Hamada K, Myoui A, Araki N, Ueda T, Itoh K, Yoshikawa H, Naka N. Trabectedin is a promising antitumor agent potentially inducing melanocytic differentiation for clear cell sarcoma. Cancer Med. 2017;6(9):2121-30

Araki N, Chuman H, Matsunobu T, Tanaka K, Katagiri H, Kunisada T, Hiruma T, Hiraga H, Morioka H, Hatano H, Asanuma K, Nishida Y, Hiraoka K, Okamoto T, Abe S, Watanuki M, Morii T, Sugiura H, Yoshida Y, Ohno T, Outani H, Yokoyama K, Shimose S, Fukuda H, Iwamoto Y. Factors associated with the decision of operative procedure for proximal femoral bone metastasis: questionnaire survey to institutions participating the Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group. J Orthop Sci. 2017;22(5):983-45

Yamada S, Imura Y, Nakai T, Nakai S, Yasuda N, Kaneko K, Outani H, Takenaka S, Hamada K, Myoui A, Araki N, Ueda T, Itoh K, Yoshikawa H, Naka N. Therapeutic potential of TAS-115 via c-MET and PDGFa signal inhibition for synovial sarcoma. BMC cancer. 2017;17(1):334

Takenaka S, Naka N, Obata H, Joyama S, Hamada K, Imura Y, Kakunaga S, Aoki Y, Ueda T, Araki N, Yoshikawa H. Treatment outcomes of Japanese patients with Ewing sarcoma: differences between skeletal and extraskeletal Ewing sarcoma. Jpn J Clin Oncol. 2016;46(6):522-8

Yasui H, Imura Y, Outani H, Hamada K, Nakai T, Yamada S, Takenaka S, Sasagawa S, Araki N, Itoh K, Myoui A, Yoshikawa H, Naka N. Trabectedin is a promising antitumor agent for synovial sarcoma. J Chemother. 2016 Oct;28(5):417-24

Imura Y, Nakai T, Yamada S, Outani H, Takenaka S, Hamada K, Araki N, Itoh K, Yoshikawa H, Naka N. Functional and therapeutic relevance of hepatocyte growth factor/c-MET signaling in synovial sarcoma. Cancer Sci. 2016;107(12):1867-76

Makino Y, Shigekawa M, Kegasawa T, Suda T, Yoshioka T, Iwahashi K, Ikezawa K, Sakamori R, Yakushijin T, Kajihara J, Tomimaru Y, Eguchi H, Imura Y, Outani H, Naka N, Honma K, Morii E, Tatsumi T, Hiramatsu N, Takehara T. A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy. Medicine(Baltimore) 2016:95(39):e4789

Outani H, Hamada K, Takenaka S, Imura Y, Oshima K, Sotobori T, Naka N, Araki N, Yoshikawa H, Myoui A. Radiofrequency ablation of osteoid osteoma using a three-demensional navigation system. J Orthop Sci. 2016; 21(5):678-82

Yamada S, Oshima K, Hamada K, Sotobori T, Joyama S, Hashimoto N, Outani H, Tanaka Y, Nakanishi K, Araki N. Giant cell tumor of the tendon sheath arising from a membrane surrounding the posterior arch of C1: a case report. Spine J 2016;16(5):e353-7

Outani H, Hamada K, Imura Y, Oshima K, Sotobori T, Demizu Y, Kakunaga S, Joyama S, Imai R, Okimoto T, Naka N, Kudawara I, Ueda T, Araki N, Kamada T, Yoshikawa H. Comparison of clinical and functional outcome between surgical treatment and carbon ion radiotherapy for pelvic chondrosarcoma. Int J Clin Oncol. 2016;21(11):186-93

Omori S, Hamada K, Outani H, Oshima K, Joyama S, Tomita Y, Naka N, Araki N, Yoshikawa H. Intraoperative extracorporeal autogenous irradiated tendon grafts for functional limb salvage surgery of soft tissue sarcomas of the wrist and hand. World J Surg Oncol. 2015;13:179

Outani H, Tanaka T, wakamatsu T, Imura Y, Hamada K, Araki N, Itoh K, Yoshikawa H, Naka N. Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), and investigation of the antitumor effects of pazopanib on Hewga-CCS. BMC Cancer. 2014 Jun 19;14:455.

Imura Y, Yasui H, Outani H, wakamatsu T, Hamada K, Nakai T, Yamada S, Myoui A, Araki N, Ueda T, Itoh K, Yoshikawa H, Naka N. Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma. Mol Cancer. 2014 Aug 7;13:185.

Imura Y, Shigi A, Outani H, Hamada K, Tamura H, MOrii E, MyouiA, Yoshikawa H, Naka N. A giant periosteal chondroma of the distal femur successfully reconstructed with synthetic bone grafts and a bioresorbable plate: a case report. World J Surg Oncol. 2014 Nov 22;12:354.

Outani H, Hamada K, Oshima K, Joyama S, Naka N, Araki N, Ueda T, Yoshikawa H. Clinical outcomes for patients with synovial sarcoma of the hand. Springerplus. 2014 Nov 3;3:649.

Yasui H, Naka N, Imura Y, Outani H, Kaneko K, Hamada K, Sasagawa S, Araki N, Ueda T, Itho K, Myoui A. Tailored therapeutic strategies for synovial sarcoma: receptor tyrosine kinase pathway analyses predict sensitivity to the mTOR inhibitor RAD001. Cancer Lett. 2014 May 28;347(1):114-22.

Hamada K, Naka N, Omori s, Outani H, Oshima K, Joyama S, Araki N, Yoshikawa H. Intercalary endoprosthesis for salvage of failed intraoperative extracorporeal autogeneous irradiated bone grafting (IORBG) reconstruction. J Surg Case Rep. 2014 Mar 7;2014(3):rju014.

Imura Y, Naka N, Outani H, Yasui H, Takenaka S, Hamada K, Ozaki R, Kaya M, Yoshida K, Morii E, Myoui A, Yoshikawa H. A novel angiomatoid epithelioid sarcoma cell line, Asra-EPS, forming tumors with large cysts containing hemorrhagic fluid in vivo. BMC Res Notes. 2013 Aug 1;6:305.

Outani H, OkadaM, Yamashita A, Nakagawa K, Yoshikawa H, Tsumaki N. Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors. PLoS One. 2013 Oct 16;8(10):e77365.

Outani H, Okada M, Hiramatsu K, Yoshikawa H, Tsumaki N. Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state. Biochem Biophys Res Commun 5;411(3):607-12.2011

Hiramatsu K, Sasagawa S, Outani H, Nakagawa K, Yoshikawa H, Tsumaki N. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture bue defined factors. J Clin Invest. 2011 Feb;121(2):640-57